Biochemist

Main Responsibilities

Working alongside a senior scientist, this role would support:

• Planning, developing, and executing a wide range of biochemical assays, including HTRF, FP, and other fluorescent-based assays for compound profiling
• The opportunity to work independently to develop rational experiments and troubleshoot when needed
• Be aware of current developments in literature and contribute pro-actively with ideas and identify opportunities in the workplace for continuous improvements
• Present results to broader project team members to help influence and drive our drug discovery projects
• Complement data streams with cellular functional assays (e.g., compound, biological or genetic perturbation endpoints such as cell health, signal transduction, etc.,)
• Employ a combination of scientific tools and methodologies in mechanistic biochemistry/enzymology/biophysics including reagent validation, binding and activity assay development, ligand-target mechanism of action studies, and compound profiling.
• Develop and execute target-relevant, fit-for-purpose biochemical/biophysical/enzymatic assays to support hit triage and progression of candidate quality molecules
• Provide enzymology/biophysics expertise to internal programs as well as external collaborations.
• Explore novel technologies
• Lead and interact with cross-functional scientific teams
• Present research activities at internal and external meetings

 

Qualifications and Experience

About you:

• Masters level scientist with a passion for biochemistry, with proven experience in assay development and enzyme development
• A high level of lab competency, and industry experience is a bonus
• A data quality perfectionist, with a flair for both the theoretical and practical, plus coding experience
• Proficient with technology (Google etc) and Automation techniques
• Independent, driven, self-directed
• A committed team player and effective, professional communicator (written, spoken, visual)
• Will thrive in, and contribute to, an inclusive, diverse, and enjoyable environment
• Experience in automated liquid handling and/or HTS and automation platforms is advantageous

 

Why join us?

Our mission at Arctoris is to generate the highest standards in data quality through the development and delivery of end-to-end automated experimentation. This entails designing and optimizing new biochemical assays, learning how to control our automation technology platform, Ulysses, to conduct those assays, and analyze the results, and the rigorous characterization of drug modalities including small molecules, peptides, antibodies, and more. Our focus is drug discovery, so you will learn about receptor pharmacology, energetics, kinetics, and mechanisms.

About us

Arctoris is a tech-enabled biopharma drug discovery company headquartered in Oxford and Boston. Arctoris combines its unique automation platform, Ulysses, with advanced computational approaches and a world-class team of seasoned drug hunters to guide and rapidly progress its wholly owned and partnered drug discovery programs in oncology and neurology. https://www.arctoris.com/