Protein Biochemist

Job Description

Description

Do you marvel at the complexity of biology and seek to develop new applications based on novel protein chemistries?

 

Do you love performing laboratory experiments in the areas of biochemistry and molecular biology with an interdisciplinary team of scientists focused on application development in the national health and defense mission areas?

 

Do you enjoy contributing to hands-on tasks in a laboratory setting?

 

If you answered yes to these questions, we’re looking for someone like you to join our team, in the Biological Sciences Group, here at the Johns Hopkins University Applied Physics Lab.

 

We are seeking an Associate Biochemistry Researcher to develop and execute strategies for recombinant protein expression, purification and characterization. You should have some combination of skills in protein purification, isolation of biochemical compounds from complex samples, biochemical assays, manipulation and analysis of DNA/RNA, and assay development. As part of the Biological Sciences Group in the Research Exploratory Development Department, this position is at the forefront of APL ‘s mission to provide critical contributions to critical challenges. A highly motivated and dedicated Biochemist will be able to contribute to building extraordinary expertise in pursuit of challenges in areas of defense and national health.

 

As a Protein Biochemist, you will…

 

Drive efforts in experimental design and execution in diverse fields to include design and manipulation of recombinant proteins and synthetic nucleic acids, protein purification and characterization.
Support study design, execution, and data analysis. You will assist and collaborate with scientists in support of laboratory-based experimentation.
Troubleshoot and optimize experimental protocols.
Assist with basic laboratory functions (i.e. lab cleanliness and organization, equipment upkeep, etc.).
Communicate key findings both internally across teams and externally to sponsors.
Be a part of a team providing leadership in the development of new opportunities and support internal initiatives, driving technical innovation and growth in areas relevant to APL sponsors.
Participate in the biology and APL community, and present data at lab meetings and to department management.

Qualifications

You meet our minimum qualifications for the job if you have …

 

B.S. in Biochemistry, Biophysics, Molecular Biology, or a similar field.
1+ years of experience in a laboratory setting.
Demonstrate proficiency with recombinant protein expression, purification and characterization.
Are well-versed in molecular biology techniques, including design and construction of genetic constructs.
Experience designing, running, and troubleshooting a wide range of biological assays.
Experience with the culturing of bacteria and yeast.
Are able to obtain a Top Secret level security clearance. If selected, you will be subject to a government security clearance investigation and must meet the requirements for access to classified information. Eligibility requirements include U.S. citizenship.

You’ll go above and beyond our minimum requirements if you have …

 

An M.S. in in Biochemistry, Biophysics, Molecular Biology or a similar field.
Experience designing and executing high-throughput biochemical and/or molecular biological assays.
Experience characterizing and engineering ice manipulating biomolecules using techniques such as thermal hysteresis measurements.
Experience purifying and working with membrane proteins.
Expirience in the area of enzyme-based material corrosion.
Experience executing assays that require the use of analytical equipment such as HPLC, GCMS, and LCMS.
Experience characterizing enzyme inhibitors.
Experience working with enzymes involved in plant secondary metabolism.
Experience setting up and/or working with multicomponent biochemical systems (e.g., multiprotein pathways reconstituted inside lipid vesicles).
Experience in protein engineering and design techniques including Molecular Dynamics Simulations, Rosetta or AlphaFold.
Experience working with proteins and other signaling cues involved in the life-cycle biology of plants and/or marine invertebrates.

 

Why work at APL?

 

The Johns Hopkins University Applied Physics Laboratory (APL) brings world-class expertise to our nation’s most critical defense, security, space and science challenges. With a wide selection of challenging, impactful work and a robust education assistance program, APL promotes a culture of life-long learning. Our employees enjoy generous benefits and healthy work/life balance. APL’s campus is located in the Baltimore-Washington metro area. Learn more about our career opportunities at www.jhuapl.edu/careers.

 

 

 

About Us

APL is an Equal Opportunity/Affirmative Action employer. All qualified applicants will receive consideration for employment without regard to race, creed, color, religion, sex, gender identity or expression, sexual orientation, national origin, age, physical or mental disability, genetic information, veteran status, occupation, marital or familial status, political opinion, personal appearance, or any other characteristic protected by applicable law. APL is committed to promoting an innovative environment that embraces diversity, encourages creativity, and supports inclusion of new ideas. In doing so, we are committed to providing reasonable accommodation to individuals of all abilities, including those with disabilities. If you require a reasonable accommodation to participate in any part of the hiring process, please contact [email protected]. Only by ensuring that everyone’s voice is heard are we empowered to be bold, do great things, and make the world a better place.

Responsibilities

Do you marvel at the complexity of biology and seek to develop new applications based on novel protein chemistries?

 

Do you love performing laboratory experiments in the areas of biochemistry and molecular biology with an interdisciplinary team of scientists focused on application development in the national health and defense mission areas?

 

Do you enjoy contributing to hands-on tasks in a laboratory setting?

 

If you answered yes to these questions, we’re looking for someone like you to join our team, in the Biological Sciences Group, here at the Johns Hopkins University Applied Physics Lab.

 

We are seeking an Associate Biochemistry Researcher to develop and execute strategies for recombinant protein expression, purification and characterization. You should have some combination of skills in protein purification, isolation of biochemical compounds from complex samples, biochemical assays, manipulation and analysis of DNA/RNA, and assay development. As part of the Biological Sciences Group in the Research Exploratory Development Department, this position is at the forefront of APL ‘s mission to provide critical contributions to critical challenges. A highly motivated and dedicated Biochemist will be able to contribute to building extraordinary expertise in pursuit of challenges in areas of defense and national health.

 

As a Protein Biochemist, you will…

 

Drive efforts in experimental design and execution in diverse fields to include design and manipulation of recombinant proteins and synthetic nucleic acids, protein purification and characterization.
Support study design, execution, and data analysis. You will assist and collaborate with scientists in support of laboratory-based experimentation.
Troubleshoot and optimize experimental protocols.
Assist with basic laboratory functions (i.e. lab cleanliness and organization, equipment upkeep, etc.).
Communicate key findings both internally across teams and externally to sponsors.
Be a part of a team providing leadership in the development of new opportunities and support internal initiatives, driving technical innovation and growth in areas relevant to APL sponsors.
Participate in the biology and APL community, and present data at lab meetings and to department management.
Knowledge and Skills

You meet our minimum qualifications for the job if you have …

 

B.S. in Biochemistry, Biophysics, Molecular Biology, or a similar field.
1+ years of experience in a laboratory setting.
Demonstrate proficiency with recombinant protein expression, purification and characterization.
Are well-versed in molecular biology techniques, including design and construction of genetic constructs.
Experience designing, running, and troubleshooting a wide range of biological assays.
Experience with the culturing of bacteria and yeast.
Are able to obtain a Top Secret level security clearance. If selected, you will be subject to a government security clearance investigation and must meet the requirements for access to classified information. Eligibility requirements include U.S. citizenship.

You’ll go above and beyond our minimum requirements if you have …

 

An M.S. in in Biochemistry, Biophysics, Molecular Biology or a similar field.
Experience designing and executing high-throughput biochemical and/or molecular biological assays.
Experience characterizing and engineering ice manipulating biomolecules using techniques such as thermal hysteresis measurements.
Experience purifying and working with membrane proteins.
Expirience in the area of enzyme-based material corrosion.
Experience executing assays that require the use of analytical equipment such as HPLC, GCMS, and LCMS.
Experience characterizing enzyme inhibitors.
Experience working with enzymes involved in plant secondary metabolism.
Experience setting up and/or working with multicomponent biochemical systems (e.g., multiprotein pathways reconstituted inside lipid vesicles).
Experience in protein engineering and design techniques including Molecular Dynamics Simulations, Rosetta or AlphaFold.
Experience working with proteins and other signaling cues involved in the life-cycle biology of plants and/or marine invertebrates.

 

Why work at APL?

 

The Johns Hopkins University Applied Physics Laboratory (APL) brings world-class expertise to our nation’s most critical defense, security, space and science challenges. With a wide selection of challenging, impactful work and a robust education assistance program, APL promotes a culture of life-long learning. Our employees enjoy generous benefits and healthy work/life balance. APL’s campus is located in the Baltimore-Washington metro area. Learn more about our career opportunities at www.jhuapl.edu/careers.

Tagged as: Biochemist